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The tumor volume of day 1, 3, 7, 14, 21 after treatment were measured, and its histological changes were also studied. The tumor-bearing nude mice were examined under the Leica LT-9 MACIMSYSPULS to detect the fluorescence. Conclusion: DCE-MRI and BOLD-MRI are adequate to observe the tumor perfusion and hypoxia during anti-vascular treatment, and the R2* value can predict the tumor metastatic potential during the process of vascular normalization. R2* value positively correlated with the positive staining rate of HIF-1α and fibronectin ( r=0.810 and 0.816), all P<0.05. The K(trans) values and tumor vessel maturity index (VMI) were higher than baseline values during 3-12 d after treatment.

The vascular maturity and microenvironment hypoxia were confirmed by pathology. DCE-MRI and BOLD-MRI were performed before and on the 3th, 6th, 9th, 12th, and 15th day after treatment.

11400700325797), which were treated with bevacizumab and saline by intraperitoneal injection on the 1st, 4th, 7th, 10th and 13th day. Sixteen nude mice were randomly divided into treatment and control groups (aged 6 to 8 weeks, weighted 15 to 18 g, Certificate No. Methods: The colon cancer xenograft model was established in BALB/C nude mice with HCT116 cell line. Objective: To explore the feasibility of dynamic-enhanced magnetic resonance imaging (DCE-MRI) and blood oxygen level-dependent MRI (BOLD-MRI) in assessing the hemodynamics and tumor aggressiveness during treatment.